Since Parkinson to multiple system atrophy
Keywords:
multisystem atrophy, Parkinson's disease, neurorehabilitation.Abstract
Parkinson's disease is the most common, but not the only one, form of parkinsonian syndrome, which is characterized by bradykinesia, rigidity, and postural instability. The objective of this article is to highlight the importance of the differential diagnosis between the two diseases in order to adapt the subsequent rehabilitation treatment. We report the case of a patient initially diagnosed with Parkinson's disease. After a year of treatment with levodopa with no improvement and together with the atypical clinical data for this disease, the possible diagnosis of multisystemic atrophy is finally reconsidered. In conclusion, small nuances in the physical examination determine the treatment and make it possible to refine the final diagnosis. From Physical Medicine and Rehabilitation, the quality of life and global functionality of the patient suffering from multisystemic atrophy can be improved.
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References
1. Lang AE, Lozano AM. Parkinson's disease. First of two parts. N Engl J Med. 1998 Oct 8;339(15):1044-53. DOI: https://doi:10.1056/NEJM199810083391506. PMID: 9761807.
2. Armstrong MJ, Okun MS. Diagnosis and Treatment of Parkinson Disease: A Review. JAMA. 2020 Feb 11;323(6):548-60. DOI: https://doi:10.1001/jama.2019.22360. PMID: 32044947.
3. Lim SY, Fox SH, Lang AE. Overview of the extranigral aspects of Parkinson disease. Arch Neurol. 2009 Feb;66(2):167-72. DOI:
https://doi:10.1001/archneurol.2008.561. PMID: 19204152.
4. Fanciulli A, Stankovic I, Krismer F, Seppi K, Levin J, Wenning GK. Multiple system atrophy. Int Rev Neurobiol. 2019;149:137-92. doi: https://doi:10.1016/bs.irn.2019.10.004. Epub 2019 Nov 21. PMID: 31779811.
5. Tison F, Yekhlef F, Chrysostome V, Sourgen C. Prevalence of multiple system atrophy. Lancet. 2000 Feb 5;355(9202):495-6. DOI:
https://doi:10.1016/S0140-6736(00)82050-4. PMID: 10841152.
6. Stefanova N, Bücke P, Duerr S, Wenning GK. Multiple system atrophy: an update. Lancet Neurol. 2009 Dec;8(12):1172-8. DOI: https://doi:10.1016/S1474-4422(09)70288-1. PMID: 19909915.
7. Bloch F, Pichon B, Bonnet AM, Pichon J, Vidailhet M, Roze E, Perrigot M. Urodynamic analysis in multiple system atrophy: characterization of detrusor-sphincter dyssynergia. J Neurol. 2010 Dec;257(12):1986-91. DOI: https://doi:10.1007/s00415-010-5645-x. Epub 2010 Aug 4. PMID: 20683607.
8. Meissner WG, Fernagut PO, Dehay B, Péran P, Traon AP, Foubert-Samier A, Lopez Cuina M, Bezard E, Tison F, Rascol O. Multiple System Atrophy: Recent Developments and Future Perspectives. Mov Disord. 2019 Nov;34(11):1629-42. DOI: https://doi:10.1002/mds.27894. Epub 2019 Nov 6. PMID: 31692132.
9. Cortelli P, Calandra-Buonaura G, Benarroch EE, Giannini G, Iranzo A, Low PA, Martinelli P, et al. Stridor in multiple system atrophy: Consensus statement on diagnosis, prognosis, and treatment. Neurology. 2019 Oct 1;93(14):630-9. DOI: https://doi:10.1212/WNL.0000000000008208. PMID: 31570638; PMCID: PMC6814413.
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