Effect of a Neuro-Restorative Program on Gait Patterns in Patients with Parkinson's Disease

Authors

Keywords:

Parkinson's disease, gait, neurorestorative rehabilitation, biomechanical analysis, quality of life

Abstract

Introduction: Parkinson's disease is a progressive neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rigidity, and gait disturbances, which significantly impact patients' autonomy and quality of life.

Objective: To evaluate the impact of a neuro-restorative program on gait patterns in patients with Parkinson's disease using biomechanical analysis.

Methods: A prospective, longitudinal, quasi-experimental study was conducted with 24 patients with Parkinson's disease treated at the International Center for Neurological Restoration. Quantitative gait assessment was performed using the SMART DTX 400 system before and after the intervention.

Results: The sample consisted of 24 patients (79% men and 21% women) with a mean age of 64.4 ± 9.5 years and a disease duration of more than five years. Hoehn and Yahr stage II were predominant. Significant improvements were observed in gait speed (p = 0.01242), stride length (p < 0.05), and gait cycle time (p < 0.05); a positive effect of the program on overall mobility was also evident.

Conclusions: The neurorestorative program proved effective in optimizing gait parameters and reducing motor impairments in patients with Parkinson's disease, supporting the value of therapeutic strategies based on rehabilitation and technology to improve their quality of life.

Downloads

Download data is not yet available.

References

1. Marín DS, Carmona H, Ibarra M, Gámez M. Enfermedad de Parkinson: fisiopatología, diagnóstico y tratamiento. Rev Univ Ind Santander Salud. 2018;50(1):79–92. DOI: http://dx.doi.org/10.18273/revsal.v50n1-2018008

2. World Health Organization. Parkinson disease. Geneva: WHO; 2023 [acceso 14/01/2025]. Disponible en: https://www.who.int/es/news-room/fact-sheetsdeta il/parkinson-disease

3. World Health Organization. Over 1 in 3 people affected by neurological conditions: the leading cause of illness and disability worldwide. Geneva: WHO; 2024. [acceso 14/01/2025] Disponible en: https://www.who.int/es/news/item/14-03-2024-over-1-in-3-people-affected-by-neurological-conditions--the-leading-cause-of-illness-and -disability-worldwide

4. Corcuera R, Patiño AF, Paima R, Chambergo D. Trastornos de la marcha y el equilibrio en adultos mayores y su asociación con diabetes mellitus tipo 2. Med Int Méx. 2021;35(5):676–84. DOI: https://doi.org/10.24245/mim.v35i5.2554

5. Udeo JP, Cedeño- MN, Moscoso GV, Meneses IP. Alteraciones sensoriales en el adulto mayor y su relación con la calidad de vida. Sinerg Académica. 2024 [acceso14/01/2025];7(Supl3):400–12. Disponible en: https://sinergiaacademica. com/index.php/sa/article/view/198

6. The Michael J. Fox Foundation. FDA reviewing four new Parkinson’s medications in 2024. New York: MJFF; 2024. [acceso 12/04/2025] Disponible en: https://www.michaeljfox.org/news/fda-reviewing-four-new-parkinsons-medicatio ns-2024

7. Armstrong MJ, Okun MS. Diagnosis and Treatment of Parkinson Disease: A Rev JAMA. 2020;323(6):548–560. DOI: https://doi.org//10.1001/jama. 2019.22360

8. El Hayek M, Lobo J, Lopes JLM, Le JH, Gregory ME, Abi Nehme AM, et al. Type, Timing, Frequency, and Durability of Outcome of Physical Therapy for Parkinson Disease: A Systematic Review and Meta-Analysis. JAMA Netw Open. 2023;6(7):e232486 DOI: https://doi.org//10.1001/jamanetworkopen.2023.24860

9. Goldman JG, Volpe D, Ellis TD, Hirsch MA, Johnson J, Wood J, et al. Delivering Multidisciplinary Rehabilitation Care in Parkinson’s Disease: An International Consensus Statement. J Parkinsons Dis. 2024;14(1):135-66. DOI: https://doi.org//10.3233/JPD-230117

10. González AG. Análisis de la marcha patológica en pacientes con enfermedad de Parkinson. [tesis de maestría]. España: Universidad de Oviedo; 2012. [acceso 12/04/2025] Disponible en: https://digibuo.uniovi.es/dspace/handle/10651/4021

11. Haro M. Laboratorio de análisis de marcha y movimiento. Rev Méd Clínica Las Condes. 2014;25(2):237. DOI: https://doi.org/10.1016/S0716-8640(14)700 34 -3

12. Cancela E. Trastornos de control de impulsos en personas con enfermedad de Parkinson: diseño de una intervención desde Terapia Ocupacional. Universidade da Coruña; 2020 [acceso 10/03/2025]. Disponible en: https://ruc.udc.es/handle/ 2183/26471

13. Martínez R, Gasca C. C, Sánchez Á, Ángel J. Actualización en la enfermedad de Parkinson. Rev Médica Clínica Las Condes. 2016;27(3):363–79. DOI: https://doi.org//10.1016/j.rmclc.2016.06.010

14. Asociación Médica Mundial. Asociación Médica Mundial (AMM). 2024. Declaración de HELSINKI de la AMM – Principios éticos para las investigaciones médicas con participantes humanos. Disponible en: https://www.wma.net/es/po licies-post/declaracion-de-helsinki/

15. Petzinger GM, Fisher BE, McEwen S, Beeler JA, Walsh JP, Jakowec MW. Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson’s disease. Lancet Neurol. 2013;12(7):716–26. DOI: https://doi.org/ 10.1016/S1474-4422(13)70123-6s

16. Rincón AG, Pantoja C, Torres JF, Tamayo CS, Rosselli D. Prevalencia y características de la enfermedad de Parkinson: análisis del registro oficial del Ministerio de Salud de Colombia. Acta Neurol Colomb. 2025;41(1). DOI: https://doi.org/10.22379/anc.v41i1.1927

17. Parkinson’s Foundation. Statistics and facts. New York: Parkinson’s Foundation; 2022 [acceso 28/04/2025]. Disponible en: https://www.parkinson.org/understanding-parkinsons/statistics

18. Su D, Cui Y, He C, Yin P, Bai R, Zhu J, et al. Projections for prevalence of Parkinson’s disease and its driving factors in 195 countries and territories to 2050: modelling study of Global Burden of Disease Study 2021. BMJ. 2025;388:e080952. DOI: https://doi.org/10.1136/bmj-2024-080952

19. Frazzitta G, Morelli M, Bertotti G, Felicetti G, Pezzoli G, Maestri R. Intensive Rehabilitation Treatment in Parkinsonian Patients with Dyskinesias: A Preliminary Study with 6-Month Followup. Parkinsons Dis. 2012;2012:14. DOI: https://doi.org/10.1155/2012/910454

20. Muthukrishnan N, Abbas JJ, Krishnamurthi N. A Wearable Sensor System to Measure Step-Based Gait Parameters for Parkinson’s Disease Rehabilitation. Sensors. 2020;20(22):6417. DOI: https://doi.org/10.3390/s20226417

21. Ferrazzoli D, Ortelli P, Zivi I, Cian V, Urso E, Ghilardi MF, et al. Efficacy of intensive multidisciplinary rehabilitation in Parkinson’s disease: a randomised controlled study. J Neurol Neurosurg Psychiatry. 2018;89(8):828–35. DOI: https://doi.org/10.1136/jnnp-2017-316437

22. Hass CJ, Malczak P, Nocera J, Stegemöller EL, Shukala A, Malaty I, et al. Quantitative Normative Gait Data in a Large Cohort of Ambulatory Persons with Parkinson’s Disease. PLoS ONE. 2012;7(8):e42337. DOI: https://doi.org/10.1371/journal.pone.0042337

23. Tomlinson CL, Patel S, Meek C, Herd CP, Clarke CE, Stowe R, et al. Physiotherapy versus placebo or no intervention in Parkinson’s disease. Cochrane Database Syst Rev. 2013;(9). DOI: https://doi.org/10.1002/14651858.CD00 2817.pub4

24. Gulcan K, Guclu A, Yasar E, Ar U, Sucullu Y, Saygili F. The effects of augmented and virtual reality gait training on balance and gait in patients with Parkinson’s disease. Acta Neurol Belg. 2023;123(5):1917–25. DOI: https://doi.org/10.1007/ s13760-022-02147-0

25. Torriente A, Dulzaides LE, Echemendía A, Sentmanat A. Influencia del programa de rehabilitación física en la marcha de pacientes parkinsonianos. Rev Cub Med Dep Cult Fís. 2022 [25/04/2025];16(2). Disponible en: https://revmedep.sld.cu/index.php/medep/article/view/492

Published

2025-12-18

How to Cite

1.
Trejo Vázquez MB, Ricardo de la Fe Y, Pavón Fuentes N, Noa Pelier BY, Ortiz Cota AM. Effect of a Neuro-Restorative Program on Gait Patterns in Patients with Parkinson’s Disease. RCMFR [Internet]. 2025 Dec. 18 [cited 2025 Dec. 25];17. Available from: https://revrehabilitacion.sld.cu/index.php/reh/article/view/1024

Issue

Section

Artículo original